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Accordingly, an AD mouse model that express mutant amyloid precursor protein (APP) and presenilin 1 (PS1) together with SREBP-2/SREBF2 displayed enhanced A accumulation and tau pathology, correlating with early oxidative damage and neuroinflammation [44]
Mitochondrial respiratory chain complexes I (NADH-CoQ reductase complex), II (succinate dehydrogenase complex), III (cytochrome bc-1 complex) can, under different metabolic stress, produce ROS that damage the mitochondrial membrane, resulting in lipid peroxidation and ultimately leading to ferroptosis
Cascajo, K.L
2 Vitamin D deficiency affects an estimated 6785% of women with PCOS, and supplementation has been associated with higher ovulation and pregnancy rates in meta-analysis
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