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However, during Phase 1 there was one report of a mild adverse reaction (lethargy, decreased appetite), and that family chose not to continue to Phase 2

doi: 10.1002/(sici)1522-7189(199902)7:1 3.0.co;2-w 9 BracarenseA

This is because extra fat tissue produces an enzyme (aromatase) that turns testosterone into estrogen, which can leave men with lower testosterone

Ibuprofen itself can irritate the stomach lining and affect platelet function, which helps blood clot