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They also commonly present with large hemorrhagic lesions as seen in this case

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During ischemia, dying neurons release massive amounts of glutamate, which overstimulates NMDA receptors on neighboring neurons, causing calcium influx and further cell death

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Kinins and small signaling peptides affect local blood flow and gland secretion

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National Library of Medicine, pubchem.ncbi.nlm.nih.gov/compound/Cagrilintide

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Conversely, overactive thyroid (hyperthyroidism) accelerates metabolism but often causes muscle loss and nutritional depletion

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