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Subjects were randomized to CHANTIX 1 mg twice daily (N=256) or placebo (N=269) for a treatment of 12 weeks and then followed for 40 weeks post-treatment

Furthermore, applying smoothed curve fitting analysis and threshold effects, an inflection point was detected at a serum cotinine level of 487 ng/ml

The country-specific relative risk for oral cancers for India was higher (RR 5.32, 95% CI 3.538.02) than no-specific estimates and for the USA remained statistically insignificant (RR 0.95, 95% CI 0.701.28)

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The target quit date for people is 7 days after initiating the medication