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We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)
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Epidemiology Cardiovascular diseases are the leading category of non-communicable diseases globally, responsible for about one-fifth of all deaths worldwide ( 2 )
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