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Beyond NSA-involving metals in the LC flow path, we also believe that ionic interactions between positively charged sites on peptides or related impurities and residual siloxide groups on commonly used silica particles can exacerbate NSA, leading to sensitivity issues and poor peak shapes

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After some weight loss is achieved and a person reaches a plateau, it is important to assess body composition. Data that is raising concern about sarcopenia as it relates to GLP-1 drugs is driven by a small portion of participants who underwent DEXA (dual-energy X-ray absorptiometry), which measures bone mineral density using spectral imaging, said Dr