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While chronic infections with HBV and HCV, heavy alcohol consumption, and diabetes are well-established primary risk factors for HCC, there is compelling and growing evidence that prolonged and active cigarette smoking is an independent and significant risk factor for its development [98, 99]

[DOI] [PubMed] [Google Scholar] [50].Perkins KA

The analyses may be refined when better dose-response data and exposure estimates become available

How Many HEETS Equal One Cigarette