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BPC-157 is a 15-amino-acid peptide that promotes healing by stimulating angiogenesis (new blood vessel formation), collagen synthesis, and growth factor activity

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FIGURE 9 Discussion Hyperglycemia-induced chronic inflammation and metabolic dysregulation play a crucial role in the micro- and macro-vascular complications of diabetes and are associated with long-term dysfunction of various organs, especially the liver and kidneys ( Despite the benefits of pharmacological therapies, prophylactic approaches such as physical exercise, besides caloric restriction are considered the cornerstone in the management of type 2 diabetes ( Our previous study in GK rat pancreas demonstrated exercise-induced beneficial effects by improving energy metabolism, antioxidant responses and mitochondrial functions, and metabolic adaptation (Raza et al., 2016)

The lipid peroxidation product 4-HNE can activate nuclear factor kappa-B (NF-B), triggering inflammatory responses (60)