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Kim HJ, Park SH, Park SY, Moon UY, Lee BD, et al: Epigallocatechin-3-gallate inhibits interleukin-1beta-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells

2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

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Retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, making it distinct from approved agents such as semaglutide (Wegovy) and tirzepatide (Mounjaro)