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Temperature excursions above 8C denature the peptide structure irreversibly, eliminating therapeutic activity

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Finally, this study should overwhelm the general point that animal studies per se may be cautious regarding their results, and the relative paucity of the BPC 157 clinical data [7,16]

ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads, by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) at 15 min, 24 h or 48 h ligation-time

This thin needle does little damage to the skin upon entry