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These included four RCTs,478, 483, 484, 485 two post-hoc analyses of previous RCTs,245, 486 and two cohort studies.487, 488 The studies were primarily focused on evaluation of dual or poly-use of conventional cigarettes and other tobacco products (e-cigarettes, waterpipes, cigars)

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In fewer cases, some users have a true allergy to PG, resulting in painful skin rashes or eczema

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