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The transition to a more severe expression of smoking-associated disease is marked by the impaired ability of macrophages to kill bacteria or viruses, the loss of ability to remove dead cells, the degradation and chemical modification of the extracellular matrix, the increasing retention of oligoclonally expanded CD8+ T cells and the induction of interleukin-17-secreting effector T cells

"Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals"

Natural and physical environments are frequently associated with the presence of physical and mental health conditions [13, 17,18,19]

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