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PMID: 27734632

Activation of the GLP-1 receptor in microglia, GABAergic interneurons and astrocytes stimulates several intracellular pathways including the PI3K/Akt, cAMP/PKA/CREB, and P-Akt/p-eNOS and subsequently confers neuroprotective effects through inhibition of gp91/CHOP, Nrf2/HO-1, Bax/Bcl-2/caspase3/PARP, NF-B/ICAM-1, and JAK2/STAT3

The second time was later that year, after an investigation showed that those findings had been fraudulent

Neuronal survival (Cerebrolysin) shows benefits developing over months as cells that would have died survive

Emerging research points to potential applications in areas such as inflammation and neurological conditions, as well as substance-use disorders, depression, psoriasis, Crohns disease and asthma