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Tavakolpournegari A, Villacorta A, Morataya-Reyes M, Arribas Arranz J, Banaei G, Pastor S, et al

After 2 weeks of treatment, mice treated with GLP-1MK-801, as well as those subjected to calorie restriction or GLP-1 monotherapy, demonstrated enhanced glucose tolerance compared with mice that were treated with the vehicle or MK-801 monotherapy (Extended Data Fig

To assess whether the anti-obesity properties of GLP-1MK-801 are dependent on this key energy balance-governing pathway, we tested the weight loss efficacy in DIO Mc4r -KO (also known as melanocortin-4 receptor) mice