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Mutations or alterations in hematopoietic stem cells raise concern for clonal hematopoiesis, a premalignant condition caused by the clonal expansion of a blood cell with the same mutations often leading to cancers such as leukemia, lymphoma, or myeloma

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In 2011, the FDAs Tobacco Products Scientific Advisory Committee reviewed the evidence and concluded that removal of menthol in cigarettes from the marketplace would benefit public health in the United States. In 2013, the FDA conducted another review and again found that menthol cigarettes posed a greater health hazard than regular cigarettes

While regulatory pressure exists, harm reduction endorsements and public acceptance among adult smokers are ensuring a sustained demand for e-cigarette and vape