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Although most closely associated with classical sickle disease (HbSS), boatshaped cells are also seen in compound heterozygotes between HbS and other abnormal haemoglobins

These participants also tended to walk faster following treatment, suggesting improved physical function

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Collectively, these results suggested that APR-017 and LCS3 treatment induce vulnerability of VRK2-deficient PC cells by GSH inhibition and consequent disruption of the balance between ROS generation and antioxidation

Individuals adhering to healthy dietary habits tend to exhibit greater microbial diversity and experience milder depressive symptoms [487, 508, 509]