Nutrition 22 , 275282 (2006)
Adults seeking the strongest available weight-loss outcome in a brand-name SKU Adults with obesity and moderate-to-severe OSA (cross-listed indication) Adults with pre-diabetes and obesity who want T2D progression prevention Clients who plateaued on a semaglutide SKU and want a tirzepatide trial Clients comfortable with weekly subcutaneous injection In SURMOUNT-5, a 72-week head-to-head trial sponsored by Eli Lilly, adults on Zepbound (tirzepatide) achieved 20.2% mean body weight loss, compared with 13.7% for adults on Wegovy (semaglutide)
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Both medications achieve clinically significant weight reduction, but tirzepatide demonstrates greater efficacy with 15-22% weight loss versus Qsymia's 6-10% in head-to-head comparisons
Methotrexate can cause mucositis (mouth ulcers and gut lining inflammation), and Wegovy can cause nausea and reduced appetite