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Most patients begin at a low dose and increase gradually over weeks, allowing their body to adapt while monitoring for metabolic improvements

This includes internal bleeding, such as in the stomach or brain, as well as bleeding that is hard to stop from minor cuts or injuries

Weight regain after stopping is a documented pattern with all GLP-1 class compounds, and Retatrutide is expected to follow the same pattern

When symptoms do manifest in more advanced disease, they tend to be non-specific and subtle