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Acetaldehyde (ADH) produces numerous deleterious effects on the liver, including the following: direct activation of stellate cells 54

Interestingly, in a mouse model of coronary atherosclerosis, hemodynamic stress was shown to induce changes in sphingolipid metabolism that favored the production of S1P over ceramides, suggesting that blood vessels may be adaptative to stress [112]

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Activities of hydrogen peroxide scavenging enzymes in germinating wheat seeds