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older, non-selective agents are available for different routes of administration [i.e., oral (PO), intramuscular (IM), and intravenous (IV)] and continue to be investigated actively (Pereira and Goudet, 2019)

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Thus, specific metal-based nanoparticle-based therapeutics have already been approved by the United States Food and Drug Administration (FDA) ( While the increasing need for novel drugs or drug-release systems has led to vast advancements in nanomedicine, some safety concerns exist (Liu et al., 2020a

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References Frey, T