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[52] In 1954, tobacco companies ran the ad "A Frank Statement." The ad was the first in a disinformation campaign, disputing reports that smoking cigarettes could cause lung cancer and had other dangerous health effects

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Firstly, NNK was found to induce a key event in initiation of pancreatitis: premature activation of digestive zymogens (trypsinogen and chymotrypsinogen)

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