That difference in half-life is why research protocols reference them at very different frequencies
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What is the recommended dose of vitamin B12 (cyanocobalamin or methylcobalamin) injection for a non-diabetic 61-year-old female with neuropathy symptoms and a vitamin B12 deficiency (level of 348 pg/mL)?
Excellent dietary sources include : Meat and poultry : beef liver (particularly rich), lamb, chicken, and turkey Fish and seafood : salmon, trout, tuna, sardines, and shellfish (especially clams and mussels) Dairy products : milk, cheese, and yoghurt provide moderate amounts Eggs : particularly the yolk contains bioavailable B12 Fortified foods : breakfast cereals, plant-based milk alternatives, fortified yeast extracts (such as Marmite), and fortified nutritional yeast For individuals following plant-based diets, fortified foods and supplements become essential , as naturally occurring B12 in plant foods is negligible or in forms poorly utilised by humans
Once the protocol is active, follow-ups are scheduled at 4 and 8 weeks for adjustment