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Efficacy of topical vitamin C in melasma and photoaging: A systematic review

3.4 Genetic alterations in GLP-1R across tumor types In cancer, genetic alterations in tumor suppressor genes typically involve loss-of-function mutations, such as deletions or truncating mutations, which occur at higher frequencies in cancers that rely on disabling growth inhibition pathways (e.g., TP53 mutations in many cancers)