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This is a mechanistically reasoned hypothesis being tested cautiously by forward-leaning practitionerswith all the risks that implies

verby, A., Stokland, R

They usually represent only a cosmetic problem and are asymptomatic, but sometimes they may be associated with itching and pain, or may be functionally important, e.g., they may cause problems to wear shoes, especially the elephantiasic form of localized myxedema

And we're now in a situation where we don't know if we're dealing with pure placebo effect or we are dealing with real effects

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