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FOXO4-DRI is among the highest-risk research peptides from an evidence-to-risk standpoint: it has never been tested in humans, no human pharmacokinetic data exists, and as a senolytic it carries theoretical risks specific to its mechanism

This is because it can be found in nearly every single cell in the body at the same concentration as some of the most important nutrients for energy and cellular function, like glucose, potassium, and even cholesterol

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doi: 10.1111/j.1600-0773.1991.tb01264.x

Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2