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Injectable GLP-1-based therapies, including semaglutide and tirzepatide, have demonstrated substantial benefits for weight loss and cardiometabolic risk reduction ( 1 3 ), but real-world uptake has been shaped by factors such as route of administration, access, tolerability, and insurance coverage ( 4 7 )

However, BMI does not capture the full spectrum of metabolic dysfunction

The experimental protocol is illustrated in Figure 1A

Study limitations Although the current findings are consistent and coherent, strongly indicating the external validity of the study, we do recommend future preferably large prospective clinical trials, to increase their internal validity

doi:10.1111/j.1365-2141.2009.07937.x