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Since AAVs have been found to integrate within DSBs with high frequency [152], the coupling of CRISPR-Cas9 with AAVs as the delivery vector must be carefully evaluated before clinical translation [58, 153]

Dr Zhou undertook the work while he was a researcher in the laboratory of Professor Zhiwei Chen, also at the University of Hong Kong

10.7554/eLife.17834 391 ZhangM.XiZ.ZinmanL.BruniA

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