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If one were to extrapolate from existing human trials: Dose: 0.51 mg per day Route: Sublingual or subcutaneous Duration: Up to 20 days (as used in circadian gene studies) Yet these regimens should not be considered prescriptive or approved protocols

On the one hand, PGC-1 stimulates mitochondrial biogenesis by enhancing NRF1 transcriptional activity and TFAM gene expression

Convenience is the absolute primary driver and systemic effects are a secondary, or even non-existent, concern

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