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Reduced sodium intake follows almost automatically from reduced total intake, which contributes independently

The trial was stopped early because benefits were so clear

Because everyones baseline levels and lifestyle stressors differ, a dose that works for one person might be excessive for another

This also raises the question whether PARP activity in BRCA1/2-deficient tumors produces a similar metabolic phenotype via NAD + depletion and whether the use of a PARP inhibitor (e.g., olaparib) to treat these tumors 10 might restore NAD + levels and counterbalance GAPDH inhibition by other oxidative agents