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But its gastrointestinal side effects (nausea, vomiting, diarrhea) can lead to dehydration, which can worsen existing kidney disease

More impressively, up to 83% of those on the highest dose lost at least 15% of their weight , compared to only 2% of placebo patients

Larger clinical studies will be required to determine whether these improvements lead to higher pregnancy rates, better birth outcomes and long-term reproductive benefits

Headache rates in SURPASS trials Across the SURPASS clinical trials, between 4% and 14% of participants reported headaches depending on the dose they received

Adequate protein intake commonly cited in weight-loss research at roughly 1.2-1.6 g per kg of body weight per day, higher for older or very active individuals is the strongest dietary signal to retain muscle in a deficit