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[56] Another review indicated that, based upon the longest follow-up studies conducted to date, lifetime stimulant therapy that begins during childhood is continuously effective for controlling ADHD symptoms and reduces the risk of developing a substance use disorder as an adult

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while US research into the smoking substitutes has focused on the potential for children to get hooked on fruity vaping flavors, the potential that children could move on to cigarettes and the detrimental effects on the cardiovascular system, public health messages in England have focused on the potential for e-cigarettes and vaping products to be used to help people quit smoking regular cigarettes

E-cigarette use could also increase risk of ever smoking (i.e., probability of transition is higher for Path 2a than 2b, holding all external confounds constant)