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483 As a nuclear receptor, the farnesoid X receptor (FXR) is overexpressed in the liver and intestine and modulates the expression of genes involved in the synthesis of cholesterol and bile acids

GLP-1 is an insulinotropic glucoincretin hormone, known to promote -cell survival via G protein-coupled receptor 40 and increase beta cell proliferation through TCF7l2/Wnt pathway 41,42,43

In addition, manufacturers need to undergo regular audits by regulatory authorities to ensure that their production facilities and quality management systems comply with GMP requirements