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Beyond the Smad pathways, TGF- also influences tissue fibrosis through non-Smad mechanisms such as the Ras-MAPK, PI3K-Akt, and Par6-Smurf1 pathways, while concurrently inhibiting the TGF--Smad pathway by encouraging I-Smad binding to active TRI, thus hindering R-Smad phosphorylation (6769)
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Prot P, Falguieres M, Arowas L, Laude H, Foy J-P, Goudot P, et al
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