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This can cause cellular changes and increased intestinal barrier permeability, leading to cell death and potentially allowing substances like bacterial toxins into the bloodstream

Iron and Oxidative Stress: Excessive iron accumulation increases non-transferrin-bound iron leading to free radical generation

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The gut microbiota can control systemic iron homeostasis by inhibiting intestinal iron absorption pathways and by increasing cellular iron storage

Ferritin serves as an essential biomarker for the body's iron storage, and elevated serum ferritin levels may signal an iron overload situation