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This is particularly common when patients first begin treatment and are still developing their injection technique

Seven CVOTs have examined the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on CV events in patients with DM and CVD: lixisenatide (ELIXA)88, exenatide (EXSCEL)73, liraglutide (LEADER)89 , 90, injectable semaglutide (SUSTAIN-6)91, oral semaglutide (PIONEER-6)92, albiglutide (Harmony Outcomes trial, no longer marketed)93 and dulaglutide (REWIND)94

Neuropharmacology, 134, 108120

Together, these actions provide a comprehensive approach to diabetes management