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Therefore, it is plausible that the increased susceptibility to disease progression and the subsequent fatal outcome in this population is related to poor angiotensin 1-7 (Ang-1-7) generation, the main peptide generated by ACE2, and probably to their inaccessibility to its anti-inflammatory effects

Nevertheless, these measures are biologically linked to smoking and have demonstrated relationships to consumption, and thus provide objective indices of smoke exposure against which self-reports can be compared

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