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Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

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Summary Keywords GSH synthesis inhibition, BSO, brain protection, xCT, Nrf2 Citation Valdovinos-Flores C, Limn-Pacheco JH, Len-Rodrguez R, Petrosyan P, Garza-Lomb C and Gonsebatt ME (2019) Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and -Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum