.22 mg semaglutide vs. Tirzepatide: How Weight-Loss Drugs Like Ozempic Work Troubling Findings in Study of

2 mg USEMA Pen Only doses of 0.25 mg or 0.5 mg can be selected with the dose selector

Increasing the dose during a short plateau can increase side effects without improving outcomes

Also, patients should avoid leaving pens in locations exposed to extreme temperatures, such as in a car, where they can become too hot or too cold

Ethics declarations Ethics Approval and Consent to Participate All experiments were conducted by the Ethical Principles in Animal Experimentation and were accepted by the Ethics Committee on the Use of Animals of the Aggeu Magalhes Institute (CEUA 135/2018-IAM)

Slower titration schedules often reduce GI side effects significantly without compromising long-term weight loss