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The gateway effect works in multiple directionsany tobacco use increases vulnerability to other forms

11 Given that the current available first-line medications are all efficacious, and non-drug factors make a substantial contribution to the likelihood of quitting successfully, 8 choice should be based on overall evidence of relative efficacy, clinical suitability and patient preference (Figure 2.2)

The key is to cut just enough to allow for a comfortable draw while preserving the structure of the cigar

E-cigarette use has also been linked with pre-symptomatic cardiovascular dysfunction

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