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The apparent permeability coefficient ( P app ) was calculated using the following equation: where Q is the change in the amount of CF over the designated period of time ( t ), A is the nominal surface area of the growth supports (i.e., 1.13 and 0.33 cm 2 in case of 3460 and 3470 Transwell inserts, respectively), and C 0 is the initial concentration of CFDA in the donor fluid

They will help deliver not just the smokefree 2030 ambition, but also the major conditions strategy, as smoking is responsible for all 6 major conditions from cancer to cardiovascular and respiratory disease, as well as dementia, mental ill health and musculoskeletal disorders

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