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Differences in the anatomy, biological processes and cell-type-specific expression patterns of the human digestive system make animal models a suboptimal choice to mimic the occurrence and treatment of human digestive diseases

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Visible fat loss and body composition changes typically appear around weeks 4 to 6, with full benefits developing over 8 to 12 weeks

These are baseline requirements for bone health that become especially important when bone resorption markers are elevated, as demonstrated in the Hansen trial