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SURPASS J-combo study comparing people with T2DM in a Japanese population with a high HbA1c on oral antihyperglycemic monotherapy on 5, 10, or 15 mg of once weekly tirzepatide for 52 weeks showed an improvement of glycemic and lipid control, weight loss and reduction in blood pressure [57]

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J Pharmacol Exp Ther (2020) 374:7483

In addition, AT remains the most commonly studied source of immune-mediated inflammation in obesity