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GPCR dynamics: structures in motion

Constant exposure to sunlight, pollution, dust, humidity, stress, and unhealthy lifestyle habits often leads to pigmentation, tanning, dullness, uneven skin tone, acne marks, and premature signs of aging

& Ober, R

In vivo studies show that muscle-specific triple knockout of FoxO1/3/4 abolishes the induction of 29 atrogenes-including E3 ligases, autophagy mediators, deubiquitinases (e.g., USP14), and proteasome subunits (e.g., Psmd11)-under catabolic stimuli, preserving muscle mass and strength (Sanchez et al., 2014)

Dutka M, Bobiski R, Francuz T, Garczorz W, Zimmer K, Ilczak T, wiertnia M, Hajduga MB