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Food and Drug Administration (FDA) Commissioner and the Center for Tobacco Products (CTP) Director stated in 2017, Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year

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These results show that, in developing a reduced-toxicant cigarette design, a balance must be struck between the lower mainstream benzo[a]pyrene, aromatic amine and CO yields (as well as reduced sidestream yields) from reduced circumference cigarettes, and the increased volatile yields resulting from lower adsorbent incorporation