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more pronounced during initial titration and at higher doses Dizziness and ataxia: Gabapentin reduces calcium channel activity in cerebellar neurons, producing coordination impairment at doses above 900 mg per day Cognitive blunting: Slowed processing speed and word-finding difficulty are reported frequently, particularly in older adults Peripheral edema: Fluid retention in the lower extremities occurs in a subset of users, with higher incidence at doses above 1,800 mg per day Nausea and gastrointestinal upset: More common during dose escalation phases

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Smoking cigarettes is correlated with infertility, premature menopause, pregnancy complications, and miscarriage