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[12] There are very old claims of betel chewing dating to at least 13,000 BP at the Kuk Swamp site in New Guinea, based on probable Areca sp

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As of 2019, it is illegal to sell nicotine products to anyone under the age of 21, and in some countries, such as New Zealand, tobacco products are banned altogether if you are born after 2008

Comprehensive review of epidemiological and animal studies on the potential carcinogenic effects of nicotine per se