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doi: 10.1039/c9tb02700a 23 MalinovskayaYMelnikovPBaklaushevVGabashviliAOsipovaNMantrovSet al

Niacinamide and Resorcinol Derivative Combinations : Niacinamide (3%) combined with 4-hexylresorcinol (0.4%) demonstrated significantly better lightening of hyperpigmented spots compared to niacinamide alone [139]

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N Engl J Med 323:565570