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10.1042/BSR20191248 39 YoonS

A hallmark symptom, therefore, of vitamin B12 deficiency is that you may feel tired or weak

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Compared to M2-type macrophages, M1-type macrophages exhibit elevated expression of hepcidin antimicrobial peptide (Hamp), ferritin heavy chain (FTH), and ferritin light chain (FTL), with reduced levels of FPN and iron regulatory proteins 1/2 (IRP1/2), demonstrating enhanced iron storage capacity ( 6.1 Macrophage recruitment mechanisms initiated by ferroptotic cells Ferroptosis occurs in various disease states, with macrophages responsible for ferroptotic cell clearance

[20, 22] These parallel the distinctive histopathological features of MS