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A major UK clinical trial published in 2019 found that, when combined with expert face-to-face support, people who used e-cigarettes to quit smoking were twice as likely to succeed as people who used other nicotine replacement products, such as patches or gum

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The toxic components of cigarettes, such as cadmium, could potentially interfere with the function of Leydig cells in the testes, which are responsible for testosterone production

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