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The significant weight-loss effectiveness of the MK-801-GLP-1 conjugate, as well as the potent hypothalamic alterations in proteins and transcripts associated with NMDA receptor-related neuroplasticity, indicate that the changes in the compounds biodistribution driven by glucagon-like peptide-1-regulated targeting might effectively bypass MK-801 delivery to vagal afferents and targeted neuronal cells within the nucleus of tractus solitarius (NTS)

These compounds do more than trigger GLP-1, they're also linked to better insulin sensitivity, lower inflammation, and a healthier gut barrier

12 HatzelmannA.SchatzM.UllrichV

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